Drug interactions
Amlodipine-benazepril + Secobarbital
Severity: Moderate
Amlodipine-benazepril and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can cause hypotension and CNS depression, adding to antihypertensive effects. Secobarbital also induces CYP3A4, which may reduce amlodipine levels with chronic use.
What this interaction means in plain words
Amlodipine-benazepril and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Additive hypotension from CNS depression, plus enzyme induction that may accelerate amlodipine metabolism.
What to do
Monitor blood pressure and adjust antihypertensive doses as needed with regular barbiturate use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Secobarbital?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can cause hypotension and CNS depression, adding to antihypertensive effects. Secobarbital also induces CYP3A4, which may reduce amlodipine levels with chronic use.
How serious is the interaction between Amlodipine-benazepril and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust antihypertensive doses as needed with regular barbiturate use.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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