Drug interactions
Amlodipine-benazepril + Simvastatin
Severity: Moderate
Amlodipine-benazepril and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine raises simvastatin exposure, increasing the risk of myopathy and rhabdomyolysis. Labeling limits the simvastatin dose when it is used with amlodipine.
What this interaction means in plain words
Amlodipine-benazepril and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Simvastatin belongs to Cardiovascular.
Why it happens
Amlodipine weakly inhibits CYP3A4-mediated metabolism of simvastatin, raising its systemic concentrations.
What to do
Do not exceed simvastatin 20 mg daily with amlodipine, or switch to a statin less dependent on CYP3A4. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Simvastatin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine raises simvastatin exposure, increasing the risk of myopathy and rhabdomyolysis. Labeling limits the simvastatin dose when it is used with amlodipine.
How serious is the interaction between Amlodipine-benazepril and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed simvastatin 20 mg daily with amlodipine, or switch to a statin less dependent on CYP3A4. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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