Drug interactions
Amlodipine-benazepril + Trimethoprim
Severity: Major
Amlodipine-benazepril and Trimethoprim: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim and ACE inhibitors both raise serum potassium, and the combination can cause clinically significant hyperkalemia. The risk is highest in older patients, those with renal impairment, diabetes or high trimethoprim doses.
What this interaction means in plain words
Amlodipine-benazepril and Trimethoprim can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-benazepril belongs to Cardiovascular; Trimethoprim belongs to Anti Bacterial.
Why it happens
Trimethoprim blocks the epithelial sodium channel in the distal nephron, reducing potassium excretion, while benazepril lowers aldosterone.
What to do
Avoid if possible or choose a non-trimethoprim antibiotic. If used, check potassium and creatinine within several days and monitor during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Trimethoprim
Frequently asked questions
Can I take Amlodipine-benazepril with Trimethoprim?
MediHelp rates the interaction as major. Amlodipine-benazepril and Trimethoprim can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trimethoprim and ACE inhibitors both raise serum potassium, and the combination can cause clinically significant hyperkalemia. The risk is highest in older patients, those with renal impairment, diabetes or high trimethoprim doses.
How serious is the interaction between Amlodipine-benazepril and Trimethoprim?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or choose a non-trimethoprim antibiotic. If used, check potassium and creatinine within several days and monitor during therapy.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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