Drug interactions
Amlodipine-perindopril + Trimethoprim
Severity: Major
Amlodipine-perindopril and Trimethoprim: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim blocks epithelial sodium channels in the distal nephron in a way similar to amiloride, and ACE inhibitors reduce aldosterone. Together they can cause clinically significant hyperkalemia, especially in older patients, those with renal impairment or diabetes, or on high trimethoprim doses.
What this interaction means in plain words
Amlodipine-perindopril and Trimethoprim can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-perindopril belongs to Cardiovascular; Trimethoprim belongs to Anti Bacterial.
Why it happens
Additive reduction of renal potassium excretion through ENaC blockade (trimethoprim) and reduced aldosterone (perindopril).
What to do
Avoid the combination where an alternative antibiotic exists; if it must be used, check serum potassium and creatinine within the first days and again during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Trimethoprim, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Trimethoprim
Frequently asked questions
Can I take Amlodipine-perindopril with Trimethoprim?
MediHelp rates the interaction as major. Amlodipine-perindopril and Trimethoprim can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trimethoprim blocks epithelial sodium channels in the distal nephron in a way similar to amiloride, and ACE inhibitors reduce aldosterone. Together they can cause clinically significant hyperkalemia, especially in older patients, those with renal impairment or diabetes, or on high trimethoprim doses.
How serious is the interaction between Amlodipine-perindopril and Trimethoprim?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antibiotic exists; if it must be used, check serum potassium and creatinine within the first days and again during therapy.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
