Drug interactions
Amlodipine-benazepril + Vardenafil
Severity: Moderate
Amlodipine-benazepril and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil lowers blood pressure through vasodilation and may add to the effect of the antihypertensive combination, causing symptomatic hypotension.
What this interaction means in plain words
Amlodipine-benazepril and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition with ACE inhibition and calcium channel blockade.
What to do
Start vardenafil at a low dose and monitor blood pressure. Counsel patients about dizziness and slow positional changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Vardenafil?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil lowers blood pressure through vasodilation and may add to the effect of the antihypertensive combination, causing symptomatic hypotension.
How serious is the interaction between Amlodipine-benazepril and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start vardenafil at a low dose and monitor blood pressure. Counsel patients about dizziness and slow positional changes.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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