Drug interactions
Amlodipine-benazepril + Verapamil
Severity: Moderate
Amlodipine-benazepril and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining verapamil with amlodipine duplicates calcium channel blockade and may cause excessive hypotension, edema or bradycardia. Verapamil also inhibits CYP3A4 and can raise amlodipine exposure.
What this interaction means in plain words
Amlodipine-benazepril and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade plus CYP3A4 inhibition by verapamil, which increases amlodipine levels.
What to do
Avoid duplicate calcium channel blocker therapy unless clearly needed, and monitor blood pressure, heart rate and edema. Reduce the amlodipine dose if hypotension or peripheral edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Amlodipine-benazepril with Verapamil?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining verapamil with amlodipine duplicates calcium channel blockade and may cause excessive hypotension, edema or bradycardia. Verapamil also inhibits CYP3A4 and can raise amlodipine exposure.
How serious is the interaction between Amlodipine-benazepril and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate calcium channel blocker therapy unless clearly needed, and monitor blood pressure, heart rate and edema. Reduce the amlodipine dose if hypotension or peripheral edema occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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