Drug interactions
Amlodipine-benazepril + Voclosporin
Severity: Moderate
Amlodipine-benazepril and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause hyperkalemia and nephrotoxicity, as can ACE inhibitors. Together they raise the risk of hyperkalemia and declining renal function. Amlodipine may also slightly raise voclosporin exposure.
What this interaction means in plain words
Amlodipine-benazepril and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive hyperkalemia and hemodynamic renal effects from calcineurin inhibition and ACE inhibition.
What to do
Monitor serum potassium, creatinine and eGFR regularly, especially at initiation and dose changes. Reduce or adjust therapy if hyperkalemia or renal decline develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Amlodipine-benazepril with Voclosporin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that can cause hyperkalemia and nephrotoxicity, as can ACE inhibitors. Together they raise the risk of hyperkalemia and declining renal function. Amlodipine may also slightly raise voclosporin exposure.
How serious is the interaction between Amlodipine-benazepril and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and eGFR regularly, especially at initiation and dose changes. Reduce or adjust therapy if hyperkalemia or renal decline develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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