Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Asenapine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Asenapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension and syncope. Combined with a three-drug antihypertensive, the hypotensive effect is additive. Asenapine may also prolong QT, which is relevant if the thiazide causes hypokalemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Asenapine belongs to Central Nervous System.
Why it happens
Additive blood pressure lowering from alpha-1 antagonism and antihypertensive pharmacodynamic effects.
What to do
Monitor orthostatic blood pressure especially at initiation and dose increases. Check potassium and consider reducing antihypertensive doses if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Asenapine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension and syncope. Combined with a three-drug antihypertensive, the hypotensive effect is additive. Asenapine may also prolong QT, which is relevant if the thiazide causes hypokalemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Asenapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure especially at initiation and dose increases. Check potassium and consider reducing antihypertensive doses if symptomatic.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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