Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Chlorpropamide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and so reduce the effectiveness of sulfonylureas such as chlorpropamide. Both drugs can also cause hyponatremia, which is more of a concern with chlorpropamide and diuretics in older adults.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Chlorpropamide belongs to Endocrine.
Why it happens
Thiazide-induced hyperglycemia opposes sulfonylurea action, and both agents can contribute to hyponatremia.
What to do
Monitor blood glucose and serum sodium after starting or changing therapy, and adjust the antidiabetic regimen as needed. Consider a safer alternative to chlorpropamide in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Chlorpropamide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose and so reduce the effectiveness of sulfonylureas such as chlorpropamide. Both drugs can also cause hyponatremia, which is more of a concern with chlorpropamide and diuretics in older adults.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium after starting or changing therapy, and adjust the antidiabetic regimen as needed. Consider a safer alternative to chlorpropamide in older patients.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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