Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Chlorthalidone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is a second thiazide-like diuretic added to hydrochlorothiazide, so the diuretic effect is duplicated. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, hyperuricemia, volume depletion and hypotension, while valsartan only partly offsets potassium loss.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Chlorthalidone belongs to Cardiovascular.
Why it happens
Duplicate inhibition of the distal tubule sodium-chloride cotransporter produces additive natriuresis and electrolyte loss.
What to do
Avoid using two thiazide-type diuretics together unless intentionally prescribed for resistant edema or hypertension. If both are used, monitor electrolytes and renal function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Chlorthalidone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone is a second thiazide-like diuretic added to hydrochlorothiazide, so the diuretic effect is duplicated. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, hyperuricemia, volume depletion and hypotension, while valsartan only partly offsets potassium loss.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together unless intentionally prescribed for resistant edema or hypertension. If both are used, monitor electrolytes and renal function closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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