Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Cyclophosphamide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may increase the myelosuppressive effect of cyclophosphamide, leading to deeper or longer neutropenia. Thiazide-induced volume depletion and electrolyte disturbance may add to chemotherapy toxicity.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Cyclophosphamide belongs to Oncology.
Why it happens
Thiazides are thought to reduce renal clearance of cyclophosphamide or its active metabolites, increasing bone marrow exposure.
What to do
Monitor complete blood counts closely during cyclophosphamide cycles and maintain hydration. Consider an alternative antihypertensive if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Cyclophosphamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Cyclophosphamide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may increase the myelosuppressive effect of cyclophosphamide, leading to deeper or longer neutropenia. Thiazide-induced volume depletion and electrolyte disturbance may add to chemotherapy toxicity.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during cyclophosphamide cycles and maintain hydration. Consider an alternative antihypertensive if marked myelosuppression occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
