Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Deflazacort
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and the corticosteroid deflazacort promote potassium loss, so combined use can cause clinically relevant hypokalemia. Corticosteroids can also cause fluid retention and raise blood pressure, opposing the antihypertensive regimen.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting from thiazide action and corticosteroid mineralocorticoid effects.
What to do
Monitor serum potassium and magnesium and blood pressure during treatment, and supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Deflazacort?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and the corticosteroid deflazacort promote potassium loss, so combined use can cause clinically relevant hypokalemia. Corticosteroids can also cause fluid retention and raise blood pressure, opposing the antihypertensive regimen.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and blood pressure during treatment, and supplement potassium if needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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