Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Drospirenone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, which adds to the potassium-raising effect of valsartan. Hydrochlorothiazide lowers potassium and may partly offset this, but hyperkalemia remains possible, especially with renal impairment.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Additive hyperkalemic effect of aldosterone antagonism by drospirenone and angiotensin receptor blockade, partly counteracted by thiazide kaliuresis.
What to do
Measure serum potassium during the first cycle of combined use and periodically thereafter. Consider a non-drospirenone contraceptive in patients with renal impairment or a history of hyperkalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Drospirenone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, which adds to the potassium-raising effect of valsartan. Hydrochlorothiazide lowers potassium and may partly offset this, but hyperkalemia remains possible, especially with renal impairment.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first cycle of combined use and periodically thereafter. Consider a non-drospirenone contraceptive in patients with renal impairment or a history of hyperkalemia.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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