Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Enoxaparin
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, can suppress aldosterone production by the adrenal gland. When combined with an angiotensin receptor blocker such as valsartan, potassium retention may be amplified and hyperkalemia can develop, particularly in patients with renal impairment or diabetes.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin-induced suppression of aldosterone synthesis adds to the potassium-retaining effect of angiotensin II receptor blockade.
What to do
Check serum potassium and creatinine at baseline and periodically during enoxaparin therapy, with closer checks in renal impairment or diabetes. Review other potassium-raising drugs and treat hyperkalemia if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Enoxaparin?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, can suppress aldosterone production by the adrenal gland. When combined with an angiotensin receptor blocker such as valsartan, potassium retention may be amplified and hyperkalemia can develop, particularly in patients with renal impairment or diabetes.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine at baseline and periodically during enoxaparin therapy, with closer checks in renal impairment or diabetes. Review other potassium-raising drugs and treat hyperkalemia if it develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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