Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Eprosartan
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Eprosartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan is another angiotensin receptor blocker, so combining it with olmesartan duplicates therapy. Dual ARB use increases the risk of hypotension, hyperkalemia and renal impairment without added benefit.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Eprosartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Eprosartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade leading to excessive renin-angiotensin system inhibition.
What to do
Avoid combining two ARBs and use a single agent. If both have been taken, monitor blood pressure, potassium and creatinine closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Eprosartan?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Eprosartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eprosartan is another angiotensin receptor blocker, so combining it with olmesartan duplicates therapy. Dual ARB use increases the risk of hypotension, hyperkalemia and renal impairment without added benefit.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Eprosartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARBs and use a single agent. If both have been taken, monitor blood pressure, potassium and creatinine closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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