Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Etrasimod
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Etrasimod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause transient heart rate slowing and atrioventricular conduction delay at initiation. Amlodipine is a dihydropyridine with little direct effect on heart rate, so a clinically relevant additive bradycardia is unlikely, though additive hypotension is possible. The concern is mainly theoretical.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Etrasimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Possible additive hemodynamic effects; etrasimod S1P-receptor modulation slows heart rate while amlodipine vasodilates.
What to do
Monitor heart rate and blood pressure when starting etrasimod. No dose change is normally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Etrasimod?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Etrasimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etrasimod can cause transient heart rate slowing and atrioventricular conduction delay at initiation. Amlodipine is a dihydropyridine with little direct effect on heart rate, so a clinically relevant additive bradycardia is unlikely, though additive hypotension is possible. The concern is mainly theoretical.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Etrasimod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting etrasimod. No dose change is normally needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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