Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fludrocortisone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone causes strong mineralocorticoid-driven potassium loss, which adds to the kaliuretic effect of hydrochlorothiazide and may cause significant hypokalemia. It also causes sodium and fluid retention that opposes the antihypertensive effect of the combination.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium excretion from mineralocorticoid receptor activation and thiazide diuresis, with opposing sodium retention.
What to do
Monitor serum potassium and blood pressure regularly and supplement potassium if needed. Valsartan may partly offset potassium loss, but do not rely on it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Fludrocortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fludrocortisone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone causes strong mineralocorticoid-driven potassium loss, which adds to the kaliuretic effect of hydrochlorothiazide and may cause significant hypokalemia. It also causes sodium and fluid retention that opposes the antihypertensive effect of the combination.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure regularly and supplement potassium if needed. Valsartan may partly offset potassium loss, but do not rely on it.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
