Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Fluvastatin
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan may inhibit hepatic OATP1B1 uptake, which could raise statin exposure. Fluvastatin is mainly metabolised by CYP2C9, and clinically important increases in myopathy risk are not well established, so the interaction is likely to be small.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Fluvastatin belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of fluvastatin by valsartan.
What to do
No routine dose change is needed. Advise the patient to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fluvastatin?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan may inhibit hepatic OATP1B1 uptake, which could raise statin exposure. Fluvastatin is mainly metabolised by CYP2C9, and clinically important increases in myopathy risk are not well established, so the interaction is likely to be small.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Advise the patient to report unexplained muscle pain or weakness.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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