Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Griseofulvin
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a CYP3A4 inducer and may reduce amlodipine concentrations, potentially weakening blood pressure control. The effect is generally modest and develops over days to weeks.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Griseofulvin belongs to Anti Fungals.
Why it happens
Induction of CYP3A4 by griseofulvin increases amlodipine metabolism.
What to do
Monitor blood pressure during and after griseofulvin treatment, and increase the amlodipine dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Griseofulvin
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Griseofulvin?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a CYP3A4 inducer and may reduce amlodipine concentrations, potentially weakening blood pressure control. The effect is generally modest and develops over days to weeks.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and after griseofulvin treatment, and increase the amlodipine dose if control is lost.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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