Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Ibuprofen
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce the antihypertensive effects of valsartan and hydrochlorothiazide. Together with an ARB and a diuretic it increases the risk of acute kidney injury, particularly in older or volume-depleted patients, and may contribute to hyperkalemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and decreased renal perfusion, opposing diuretic and ARB effects and impairing glomerular filtration.
What to do
Use the lowest effective ibuprofen dose for the shortest time, maintain hydration, and monitor blood pressure, creatinine and potassium. Choose paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Ibuprofen?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can reduce the antihypertensive effects of valsartan and hydrochlorothiazide. Together with an ARB and a diuretic it increases the risk of acute kidney injury, particularly in older or volume-depleted patients, and may contribute to hyperkalemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ibuprofen dose for the shortest time, maintain hydration, and monitor blood pressure, creatinine and potassium. Choose paracetamol where suitable.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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