Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Istradefylline
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses, istradefylline weakly inhibits CYP3A4 and may increase amlodipine exposure, with possible hypotension or edema. The effect is not expected at the lower dose.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits CYP3A4 at higher doses, reducing amlodipine clearance.
What to do
Monitor blood pressure if istradefylline 40 mg/day is used. Reduce the amlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Istradefylline?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At higher doses, istradefylline weakly inhibits CYP3A4 and may increase amlodipine exposure, with possible hypotension or edema. The effect is not expected at the lower dose.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if istradefylline 40 mg/day is used. Reduce the amlodipine dose if hypotension or edema develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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