Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Ivosidenib
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower amlodipine exposure, which can reduce blood pressure control. The effect is usually gradual and manageable.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing amlodipine metabolism.
What to do
Monitor blood pressure after ivosidenib is started or stopped. Increase the amlodipine dose or add another agent if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Ivosidenib?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower amlodipine exposure, which can reduce blood pressure control. The effect is usually gradual and manageable.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after ivosidenib is started or stopped. Increase the amlodipine dose or add another agent if control is lost.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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