Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Larotrectinib
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory potential in vitro, so a small rise in amlodipine exposure is conceivable. A clinically meaningful effect is not established.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition reducing amlodipine metabolism; not well characterized.
What to do
No empirical adjustment is needed; monitor blood pressure and peripheral edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Larotrectinib?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory potential in vitro, so a small rise in amlodipine exposure is conceivable. A clinically meaningful effect is not established.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical adjustment is needed; monitor blood pressure and peripheral edema.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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