Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Nifedipine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine and amlodipine are both dihydropyridine calcium channel blockers, so combining them is therapeutically duplicative. It adds to the risk of hypotension, reflex tachycardia and peripheral edema without added benefit.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Duplicate dihydropyridine calcium channel blockade with additive vasodilation.
What to do
Avoid using two dihydropyridines together and stop one of them. Monitor blood pressure and edema if a transition period is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Nifedipine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nifedipine and amlodipine are both dihydropyridine calcium channel blockers, so combining them is therapeutically duplicative. It adds to the risk of hypotension, reflex tachycardia and peripheral edema without added benefit.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two dihydropyridines together and stop one of them. Monitor blood pressure and edema if a transition period is needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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