Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Ofloxacin
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin is renally eliminated, and thiazide-related volume depletion may modestly raise its levels. Fluoroquinolones can also cause QT prolongation, which is more likely if the diuretic causes hypokalemia or hypomagnesemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Possible reduced renal clearance of ofloxacin and diuretic-induced electrolyte disturbance increasing QT risk.
What to do
Correct potassium and magnesium before and during ofloxacin therapy and adjust the dose in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Ofloxacin?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ofloxacin is renally eliminated, and thiazide-related volume depletion may modestly raise its levels. Fluoroquinolones can also cause QT prolongation, which is more likely if the diuretic causes hypokalemia or hypomagnesemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during ofloxacin therapy and adjust the dose in renal impairment.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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