Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Pazopanib
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Pazopanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits OATP1B1 in vitro, so valsartan exposure could theoretically rise. Pazopanib itself commonly causes hypertension, which may be more relevant clinically.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Pazopanib belongs to Oncology.
Why it happens
Possible inhibition of hepatic OATP1B1 uptake of valsartan, an in vitro finding not clearly confirmed clinically.
What to do
Monitor blood pressure, as pazopanib-related hypertension may require antihypertensive adjustment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Pazopanib?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pazopanib inhibits OATP1B1 in vitro, so valsartan exposure could theoretically rise. Pazopanib itself commonly causes hypertension, which may be more relevant clinically.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Pazopanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, as pazopanib-related hypertension may require antihypertensive adjustment.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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