Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Propranolol
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol adds to the blood pressure lowering of the triple combination and may cause bradycardia, hypotension or fatigue. It is frequently combined intentionally, but dose changes should be gradual. Thiazides may modestly worsen glucose and lipid effects.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects, with mild negative inotropy and chronotropy added to vasodilation.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses and reduce doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Propranolol?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol adds to the blood pressure lowering of the triple combination and may cause bradycardia, hypotension or fatigue. It is frequently combined intentionally, but dose changes should be gradual. Thiazides may modestly worsen glucose and lipid effects.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses and reduce doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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