Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Repaglinide
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is a substrate of hepatic OATP1B1 uptake, and repaglinide is a reported OATP1B1 inhibitor in vitro. A clinically relevant rise in valsartan exposure is not well established. Antihypertensive and glucose-lowering effects are otherwise independent.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan, predicted from in vitro data.
What to do
No dose change is usually needed. Monitor blood pressure when starting or stopping repaglinide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Repaglinide?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is a substrate of hepatic OATP1B1 uptake, and repaglinide is a reported OATP1B1 inhibitor in vitro. A clinically relevant rise in valsartan exposure is not well established. Antihypertensive and glucose-lowering effects are otherwise independent.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor blood pressure when starting or stopping repaglinide.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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