Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Rifabutin
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may lower amlodipine concentrations, reducing blood pressure control. The induction is weaker than with rifampicin but may still be significant during prolonged therapy.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Rifabutin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 by rifabutin, increasing amlodipine metabolism.
What to do
Monitor blood pressure after starting or stopping rifabutin. Increase the amlodipine dose or use a different antihypertensive if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Rifabutin?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may lower amlodipine concentrations, reducing blood pressure control. The induction is weaker than with rifampicin but may still be significant during prolonged therapy.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping rifabutin. Increase the amlodipine dose or use a different antihypertensive if control is lost.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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