Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Rocuronium
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may modestly potentiate non-depolarizing neuromuscular blockers, which can prolong paralysis or delay recovery. The effect is usually small with amlodipine and is relevant mainly in the perioperative setting.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Rocuronium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade may reduce prejunctional acetylcholine release, adding to neuromuscular blockade.
What to do
Use quantitative neuromuscular monitoring and titrate rocuronium to effect. Ensure full recovery before extubation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Rocuronium
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Rocuronium?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may modestly potentiate non-depolarizing neuromuscular blockers, which can prolong paralysis or delay recovery. The effect is usually small with amlodipine and is relevant mainly in the perioperative setting.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use quantitative neuromuscular monitoring and titrate rocuronium to effect. Ensure full recovery before extubation.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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