Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Salmeterol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydrochlorothiazide and beta-2 agonists such as salmeterol can lower serum potassium. The combination may produce clinically important hypokalemia, particularly at high doses or in acute asthma. Hypokalemia may provoke arrhythmias.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia from thiazide-induced renal potassium loss and beta-2 agonist-driven intracellular potassium shift.
What to do
Monitor serum potassium, especially in patients with severe asthma or COPD, heart disease, or those taking other kaliuretic drugs. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Salmeterol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both hydrochlorothiazide and beta-2 agonists such as salmeterol can lower serum potassium. The combination may produce clinically important hypokalemia, particularly at high doses or in acute asthma. Hypokalemia may provoke arrhythmias.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially in patients with severe asthma or COPD, heart disease, or those taking other kaliuretic drugs. Replace potassium as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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