Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Tadalafil
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil is a vasodilator, and combining it with amlodipine, valsartan and hydrochlorothiazide can cause additive blood pressure lowering. Patients may experience dizziness or symptomatic hypotension, particularly when starting tadalafil.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation through PDE5 inhibition and antihypertensive effects.
What to do
Start tadalafil at a low dose and monitor blood pressure. Counsel patients on orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Tadalafil?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil is a vasodilator, and combining it with amlodipine, valsartan and hydrochlorothiazide can cause additive blood pressure lowering. Patients may experience dizziness or symptomatic hypotension, particularly when starting tadalafil.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at a low dose and monitor blood pressure. Counsel patients on orthostatic symptoms.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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