Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Timolol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol, even as eye drops, can be systemically absorbed and may add to blood pressure lowering and bradycardia from the antihypertensive combination. Oral timolol has a larger effect. Beta blockers may also mask hypoglycemia and worsen glucose or lipid effects of thiazides.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta blockade, vasodilation, RAAS blockade and diuresis.
What to do
Monitor blood pressure and heart rate, especially with oral timolol or in patients with conduction disease. Adjust doses if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Timolol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Timolol, even as eye drops, can be systemically absorbed and may add to blood pressure lowering and bradycardia from the antihypertensive combination. Oral timolol has a larger effect. Beta blockers may also mask hypoglycemia and worsen glucose or lipid effects of thiazides.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially with oral timolol or in patients with conduction disease. Adjust doses if hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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