Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Triamterene
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Triamterene: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a potassium-sparing diuretic and combined with valsartan can cause clinically important hyperkalemia, especially with renal impairment, diabetes or advanced age. Hydrochlorothiazide lowers potassium and partly counters this, though the net result is unpredictable. Triamterene with an ARB also raises the risk of acute kidney injury.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Additive potassium retention from ENaC blockade and angiotensin receptor blockade, partly opposed by thiazide-induced potassium loss.
What to do
Monitor serum potassium and renal function soon after starting and periodically thereafter. Avoid potassium supplements and stop triamterene if hyperkalemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Triamterene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Triamterene?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triamterene is a potassium-sparing diuretic and combined with valsartan can cause clinically important hyperkalemia, especially with renal impairment, diabetes or advanced age. Hydrochlorothiazide lowers potassium and partly counters this, though the net result is unpredictable. Triamterene with an ARB also raises the risk of acute kidney injury.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function soon after starting and periodically thereafter. Avoid potassium supplements and stop triamterene if hyperkalemia occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
