Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Valganciclovir
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with ganciclovir, the active metabolite of valganciclovir, for renal tubular secretion. Levels may rise slightly, adding to the risk of myelosuppression, especially with reduced renal function. Diuretic-related volume depletion could further reduce ganciclovir clearance.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Valganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular anionic secretion, reducing ganciclovir clearance.
What to do
Monitor renal function and complete blood counts during valganciclovir therapy. Adjust the valganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Valganciclovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Valganciclovir?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may compete with ganciclovir, the active metabolite of valganciclovir, for renal tubular secretion. Levels may rise slightly, adding to the risk of myelosuppression, especially with reduced renal function. Diuretic-related volume depletion could further reduce ganciclovir clearance.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and complete blood counts during valganciclovir therapy. Adjust the valganciclovir dose to creatinine clearance.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
