Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Valsartan
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains valsartan, so adding more valsartan duplicates therapy and increases the risk of hypotension, hyperkalemia and renal impairment.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Therapeutic duplication of angiotensin II receptor blockade.
What to do
Avoid giving valsartan separately and review the regimen to remove the duplicate. Monitor blood pressure, potassium and creatinine if an overdose of valsartan is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Valsartan?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination product already contains valsartan, so adding more valsartan duplicates therapy and increases the risk of hypotension, hyperkalemia and renal impairment.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving valsartan separately and review the regimen to remove the duplicate. Monitor blood pressure, potassium and creatinine if an overdose of valsartan is suspected.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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