Drug interactions
Amlodipine-olmesartan + Atogepant
Severity: Minor
Amlodipine-olmesartan and Atogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and atogepant is a CYP3A4 substrate, so atogepant exposure may rise slightly. The effect is generally small and not clinically significant.
What this interaction means in plain words
Amlodipine-olmesartan and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Atogepant belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of atogepant by amlodipine.
What to do
No dose adjustment is generally required; watch for atogepant adverse effects such as constipation and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan with Atogepant?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amlodipine is a weak CYP3A4 inhibitor and atogepant is a CYP3A4 substrate, so atogepant exposure may rise slightly. The effect is generally small and not clinically significant.
How serious is the interaction between Amlodipine-olmesartan and Atogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; watch for atogepant adverse effects such as constipation and nausea.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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