Drug interactions
Armodafinil + Atogepant
Severity: Moderate
Armodafinil and Atogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak to moderate CYP3A4 inducer and may lower atogepant exposure. This may reduce migraine preventive efficacy.
What this interaction means in plain words
Armodafinil and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Atogepant belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases the metabolism of atogepant.
What to do
Use the labeled atogepant dose adjustment for CYP3A4 inducers (30 mg or 60 mg daily) and monitor migraine control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
- Atogepant + Chloramphenicol Moderate
Frequently asked questions
Can I take Armodafinil with Atogepant?
MediHelp rates the interaction as moderate. Armodafinil and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak to moderate CYP3A4 inducer and may lower atogepant exposure. This may reduce migraine preventive efficacy.
How serious is the interaction between Armodafinil and Atogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the labeled atogepant dose adjustment for CYP3A4 inducers (30 mg or 60 mg daily) and monitor migraine control.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
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