Drug interactions
Amobarbital + Atogepant
Severity: Moderate
Amobarbital and Atogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4 and may reduce atogepant exposure, which could diminish migraine prevention. Labeling advises dose adjustment with CYP3A4 inducers.
What this interaction means in plain words
Amobarbital and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Atogepant belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases atogepant metabolism.
What to do
Use an atogepant dose in line with labeling for concomitant CYP3A4 inducers and monitor migraine frequency.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Atogepant
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
- Atogepant + Chloramphenicol Moderate
Frequently asked questions
Can I take Amobarbital with Atogepant?
MediHelp rates the interaction as moderate. Amobarbital and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces CYP3A4 and may reduce atogepant exposure, which could diminish migraine prevention. Labeling advises dose adjustment with CYP3A4 inducers.
How serious is the interaction between Amobarbital and Atogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an atogepant dose in line with labeling for concomitant CYP3A4 inducers and monitor migraine frequency.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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