Drug interactions
Apalutamide + Atogepant
Severity: Moderate
Apalutamide and Atogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and reduces atogepant exposure, which may weaken migraine prevention.
What this interaction means in plain words
Apalutamide and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Atogepant belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP3A4, increasing atogepant metabolism.
What to do
Use atogepant 30 mg or 60 mg once daily as labeled for strong CYP3A4 inducers. Monitor migraine frequency.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
- Atogepant + Chloramphenicol Moderate
Frequently asked questions
Can I take Apalutamide with Atogepant?
MediHelp rates the interaction as moderate. Apalutamide and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and reduces atogepant exposure, which may weaken migraine prevention.
How serious is the interaction between Apalutamide and Atogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use atogepant 30 mg or 60 mg once daily as labeled for strong CYP3A4 inducers. Monitor migraine frequency.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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