Drug interactions
Amlodipine-olmesartan + Carbamazepine
Severity: Moderate
Amlodipine-olmesartan and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong inducer of CYP3A4 and can lower amlodipine concentrations, which may weaken blood pressure control. Olmesartan is not meaningfully affected.
What this interaction means in plain words
Amlodipine-olmesartan and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induction of CYP3A4 increases amlodipine metabolism and reduces its exposure.
What to do
Monitor blood pressure after starting or stopping carbamazepine and increase the amlodipine dose if needed. Reassess the dose if carbamazepine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Carbamazepine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine is a strong inducer of CYP3A4 and can lower amlodipine concentrations, which may weaken blood pressure control. Olmesartan is not meaningfully affected.
How serious is the interaction between Amlodipine-olmesartan and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping carbamazepine and increase the amlodipine dose if needed. Reassess the dose if carbamazepine is withdrawn.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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