Drug interactions
Carbamazepine + Delamanid
Severity: Contraindicated
Carbamazepine and Delamanid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong CYP3A4 inducer and may lower delamanid exposure. Reduced levels may compromise efficacy in drug-resistant tuberculosis and promote resistance.
What this interaction means in plain words
Carbamazepine and Delamanid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Delamanid belongs to Anti Bacterial.
Why it happens
Carbamazepine induces CYP3A4, increasing delamanid metabolism.
What to do
Avoid; switch to a non-inducing anticonvulsant where possible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Delamanid
- Delamanid + Rifampicin Contraindicated
- Delamanid + Moxifloxacin Major
- Delamanid + Ritonavir Major
- Delamanid + Ethambutol Minor
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
- Carbamazepine + Ensitrelvir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Delamanid?
MediHelp rates the interaction as contraindicated. Carbamazepine and Delamanid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine is a strong CYP3A4 inducer and may lower delamanid exposure. Reduced levels may compromise efficacy in drug-resistant tuberculosis and promote resistance.
How serious is the interaction between Carbamazepine and Delamanid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; switch to a non-inducing anticonvulsant where possible.
What other medicines interact with Delamanid?
MediHelp also lists interactions of Delamanid with, for example, Rifampicin, Moxifloxacin, Ritonavir. The full list is on the Delamanid page.
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