Drug interactions
Carbamazepine + Doravirine
Severity: Contraindicated
Carbamazepine and Doravirine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine markedly lowers doravirine concentrations through CYP3A induction, risking loss of virologic response and resistance. Labeling contraindicates strong CYP3A inducers.
What this interaction means in plain words
Carbamazepine and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Doravirine belongs to Anti Virals.
Why it happens
Carbamazepine induces CYP3A4, increasing doravirine clearance.
What to do
Do not coadminister; use an alternative anticonvulsant or antiretroviral.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
- Carbamazepine + Ensitrelvir Contraindicated
Other interactions of Doravirine
- Amobarbital + Doravirine Contraindicated
- Apalutamide + Doravirine Contraindicated
- Doravirine + Efavirenz Contraindicated
- Doravirine + Enzalutamide Contraindicated
- Doravirine + Mitotane Contraindicated
- Doravirine + Phenobarbitone Contraindicated
Frequently asked questions
Can I take Carbamazepine with Doravirine?
MediHelp rates the interaction as contraindicated. Carbamazepine and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine markedly lowers doravirine concentrations through CYP3A induction, risking loss of virologic response and resistance. Labeling contraindicates strong CYP3A inducers.
How serious is the interaction between Carbamazepine and Doravirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative anticonvulsant or antiretroviral.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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