Drug interactions
Amlodipine-olmesartan + Clarithromycin
Severity: Moderate
Amlodipine-olmesartan and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits CYP3A4 and can raise amlodipine concentrations, leading to hypotension, peripheral edema and in some reports acute kidney injury. Older patients appear to be at particular risk.
What this interaction means in plain words
Amlodipine-olmesartan and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by clarithromycin increases amlodipine exposure.
What to do
Monitor blood pressure and renal function during clarithromycin therapy, and consider an alternative macrolide such as azithromycin or a temporary amlodipine dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Clarithromycin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin inhibits CYP3A4 and can raise amlodipine concentrations, leading to hypotension, peripheral edema and in some reports acute kidney injury. Older patients appear to be at particular risk.
How serious is the interaction between Amlodipine-olmesartan and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during clarithromycin therapy, and consider an alternative macrolide such as azithromycin or a temporary amlodipine dose reduction.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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