Drug interactions
Amlodipine-olmesartan + Clevidipine
Severity: Moderate
Amlodipine-olmesartan and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clevidipine is an intravenous dihydropyridine calcium channel blocker, so adding it to amlodipine gives duplicate therapy and additive vasodilation. Excess hypotension and reflex tachycardia may occur.
What this interaction means in plain words
Amlodipine-olmesartan and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Clevidipine belongs to Cardiovascular.
Why it happens
Additive L-type calcium channel blockade producing arterial vasodilation.
What to do
Titrate clevidipine cautiously with continuous blood pressure monitoring, and consider holding oral amlodipine during infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Amlodipine-olmesartan with Clevidipine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clevidipine is an intravenous dihydropyridine calcium channel blocker, so adding it to amlodipine gives duplicate therapy and additive vasodilation. Excess hypotension and reflex tachycardia may occur.
How serious is the interaction between Amlodipine-olmesartan and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine cautiously with continuous blood pressure monitoring, and consider holding oral amlodipine during infusion.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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