Drug interactions
Amlodipine-benazepril + Clevidipine
Severity: Moderate
Amlodipine-benazepril and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clevidipine and amlodipine are both dihydropyridine calcium channel blockers, so the combination produces additive vasodilation. Excessive hypotension and reflex tachycardia may occur, particularly because clevidipine is titrated rapidly to effect.
What this interaction means in plain words
Amlodipine-benazepril and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Clevidipine belongs to Cardiovascular.
Why it happens
Additive L-type calcium channel blockade in vascular smooth muscle.
What to do
Monitor blood pressure continuously during clevidipine infusion and titrate cautiously. Account for the long-acting amlodipine already on board when choosing infusion rates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Amlodipine-benazepril with Clevidipine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clevidipine and amlodipine are both dihydropyridine calcium channel blockers, so the combination produces additive vasodilation. Excessive hypotension and reflex tachycardia may occur, particularly because clevidipine is titrated rapidly to effect.
How serious is the interaction between Amlodipine-benazepril and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during clevidipine infusion and titrate cautiously. Account for the long-acting amlodipine already on board when choosing infusion rates.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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