Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Clevidipine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clevidipine is a dihydropyridine calcium channel blocker, so together with amlodipine there is duplicate therapy and additive vasodilation. Excessive hypotension and reflex tachycardia may result, although clevidipine is short-acting and titrated to effect.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Clevidipine belongs to Cardiovascular.
Why it happens
Additive L-type calcium channel blockade causing arterial vasodilation.
What to do
Titrate clevidipine against continuous blood pressure monitoring and use lower infusion rates if the patient has taken their oral combination product.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Clevidipine
- Aldesleukin + Clevidipine Moderate
- Alfuzosin + Clevidipine Moderate
- Amlodipine-atorvastatin + Clevidipine Moderate
- Amlodipine-benazepril + Clevidipine Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Clevidipine Moderate
- Amlodipine-olmesartan + Clevidipine Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Clevidipine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clevidipine is a dihydropyridine calcium channel blocker, so together with amlodipine there is duplicate therapy and additive vasodilation. Excessive hypotension and reflex tachycardia may result, although clevidipine is short-acting and titrated to effect.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine against continuous blood pressure monitoring and use lower infusion rates if the patient has taken their oral combination product.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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