Drug interactions
Amlodipine-atorvastatin + Clevidipine
Severity: Moderate
Amlodipine-atorvastatin and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clevidipine and amlodipine are both dihydropyridine calcium channel blockers, so combining them adds vasodilation and may cause excessive hypotension and reflex tachycardia. Clevidipine is titrated intravenously and its effect is quickly reversible.
What this interaction means in plain words
Amlodipine-atorvastatin and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Clevidipine belongs to Cardiovascular.
Why it happens
Additive L-type calcium channel blockade causing vasodilation.
What to do
Monitor blood pressure continuously during clevidipine titration and adjust the infusion rate, holding or reducing amlodipine if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Clevidipine
Frequently asked questions
Can I take Amlodipine-atorvastatin with Clevidipine?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clevidipine and amlodipine are both dihydropyridine calcium channel blockers, so combining them adds vasodilation and may cause excessive hypotension and reflex tachycardia. Clevidipine is titrated intravenously and its effect is quickly reversible.
How serious is the interaction between Amlodipine-atorvastatin and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during clevidipine titration and adjust the infusion rate, holding or reducing amlodipine if hypotension occurs.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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