Drug interactions
Amlodipine-olmesartan + Crizotinib
Severity: Moderate
Amlodipine-olmesartan and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may increase amlodipine exposure, causing hypotension and edema. Crizotinib can also cause bradycardia, which may add to cardiovascular effects.
What this interaction means in plain words
Amlodipine-olmesartan and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Crizotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by crizotinib.
What to do
Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if hypotension or marked edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Crizotinib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and may increase amlodipine exposure, causing hypotension and edema. Crizotinib can also cause bradycardia, which may add to cardiovascular effects.
How serious is the interaction between Amlodipine-olmesartan and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if hypotension or marked edema develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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