Drug interactions
Crizotinib + Lomitapide
Severity: Contraindicated
Crizotinib and Lomitapide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and lomitapide is a sensitive CYP3A4 substrate, so exposure to lomitapide can rise markedly. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Crizotinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Crizotinib belongs to Oncology; Lomitapide belongs to Cardiovascular.
Why it happens
Crizotinib inhibits CYP3A4, reducing first-pass and systemic metabolism of lomitapide.
What to do
Avoid the combination; labeling for lomitapide advises against moderate and strong CYP3A4 inhibitors. Use an alternative lipid-lowering strategy during crizotinib treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
- Adagrasib + Crizotinib Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
- Erythromycin + Lomitapide Contraindicated
Frequently asked questions
Can I take Crizotinib with Lomitapide?
MediHelp rates the interaction as contraindicated. Crizotinib and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Crizotinib is a moderate CYP3A4 inhibitor and lomitapide is a sensitive CYP3A4 substrate, so exposure to lomitapide can rise markedly. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Crizotinib and Lomitapide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling for lomitapide advises against moderate and strong CYP3A4 inhibitors. Use an alternative lipid-lowering strategy during crizotinib treatment.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lonafarnib, Pimozide. The full list is on the Crizotinib page.
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